Efecto kindling producido por un foco penicilínico amigdalino, en preparaciones crónicas de gato. Estudio polisomnográfico (registros de 23 horas) y de mapeo cerebral

  1. Adrián Martínez Cervantes 1
  2. Rodrigo Fernández-Mas 1
  3. Edith López 1
  4. Germán Vega 1
  5. Augusto Fernández-Guardiola 2
  1. 1 Instituto Nacional de Psiquiatría Ramón de la Fuente
  2. 2 Facultad de Psicología, UNAM
Aldizkaria:
Salud mental

ISSN: 0185-3325

Argitalpen urtea: 2000

Alea: 23

Zenbakia: 5

Orrialdeak: 26-34

Mota: Artikulua

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Beste argitalpen batzuk: Salud mental

Laburpena

The effect of repeated “G” sodic penicilin (Pn) microinjections (50-250 UI/1µ1) in the temporal lobe amygdala (AM) of freemoving cats was investigated. The following variables were measured: a) the time of appearance of the epileptiform spikes in the injected amygdala, b) the duration and frecuency of the afterdischarges, c) the time of propagation to the cerebral cortex of both hemispheres and to the contralateral AM, d) the dose-response relationship for generalized convulsive seizures, e) the topographic distribution of the spike projection to the cerebral cortex, measured by brain topographic mapping technics, f) the progressive behavioral changes evolution analyzed in videotape. Results show that the microinjection of Pn in the AM is a realiable model of interictal spikes, paroxysms and generalized convulsive seizures, having similar characteristics as those of electrical kindling. The Pn repeated microinjection does not produce important changes in the layout and organization of sleep; the only important change was an increase in rapid eye movements sleep (REM) latency. A significant finding in this experiment was that the appearance of PGO spikes in both lateral geniculate bodies always coincide with a depression of the frecuency and amplitude of the interictal amygdaline spikes

Erreferentzia bibliografikoak

  • BERTASHIUS KM: Propagation of human complex-partial seizures: a correlation analysis. Electroenceph Clin Neurophysiol, 78:333-340, 1991.
  • CALVO JM, FERNANDEZ-GUARDIOLA A: Phasic activity of the basolateral amygdala, cingulate gyrus, and hippocampus during rem sleep in the cat. Sleep, 7(3):202-210, 1984.
  • CALVO JM, FERNANDEZ-MAS R: Amygdaloid during wakefulness and paradoxical sleep in the cat. Sleep organization changes produced by kindling development. Epilepsy Res, 9:175-183, 1991.
  • CALVO JM, FERNANDEZ-MAS R: Transitory and shortduration changes of sleep organization provoked by amygdaloid kindling in the cat. A daily 23-hour sleep recording study. Epilepsy Res, 19:1-13, 1994.
  • CHATT AB, EBERSOLE JS: Comparison between strychnine and penicillin epileptogenesis suggest that propagating epileptiform abnormalities require the potentation of thalamocortical circuitry in neocortical layer 4. Exp Neurol, 100:365-380, 1988.
  • COLLINS RC: Kindling of neuroanatomic pathways during recurrent focal penicilin seizures. Brain Res, 150:503-517,1978.
  • DICHTER MA, AYALA GF: Cellular mechanism of epilepsy: a status report. Science, 237:157-164, 1987.
  • DOW RS, FERNANDEZ-GUARDIOLA A, MANNI E: The influence of the cerebellum on experimental epilepsy. Electroenceph Clin Neurophysiol, 14:383-398, 1962.
  • FERNANDEZ-GUARDIOLA A, MARTINEZ A, GUTIERREZ R, FERNANDEZ-MAS R: Amygdaline penicillin focus replicates and modulates electrical amygdaloid in the cat. Proc West Pharmacol West Soc, 43:219-222, 1991.
  • FERNANDEZ-GUARDIOLA A, MARTINEZ A, FERNANDEZ- MAS R: Repeated penicillin-induced amygdala epileptic focus in freely moving cats. EEG, polysomnographic (23 h recording), and brain mapping study. Epilepsy Res, 22:127-136, 1995.
  • FERNANDEZ-GUARDIOLA A, SOLIS H, JURADO JL, SALGADO A, JIMENEZ S: Aplicación tópica de penicilina en el lóbulo anterior del cerebelo: un nuevo modelo de descarga mioclónica. Rev Inst Nal Neurol (Méx), 10:153- 163, 1976.
  • FERNANDEZ-MAS R, MARTINEZ A, GUTIERREZ R, FERNANDEZ-GUARDIOLA A: EEG frequency and time domain mapping study of cortical projections of temporal lobe amygdala afterdischarge during in the cat. Epilepsy Res, 13:23-34, 1992.
  • FURSET K, ENGELSEN BA: Penicillin-Induced convulsions have preferencial effects on tansmitter glutamate pools in rat neostriatum. Neurochem Res, 14:1143-1147,1989.
  • GASTEIGER LE, ALBOWITZ B, BARKEN MF: Interictal afterdischarge in focal penicillin epilepsy: Block by thalamic cooling. Exp Neurol, 88:349-359, 1985.
  • GLOOR P, QUESNEY LF, ZUMSTEIN H: Pathophysiology of generalized epilepsy in the cat: The role of cortical and subcortical structures. II Topical application of penicillin to the cerebral cortex and to subcortical structures.Electroenceph Clin Neurophysiol, 43:79-94, 1977.
  • GODDARD GV, MCINTYRE DC, LEECH CK: A permanent change in brain function resulting from daily electrical stimulation. Exp Neurol, 25:295-330, 1969.
  • GRANATO A, SANTARELLI M, MINCHIACCHI D: Bihemispheric organization of amygdalo-cortical proyections int he rat. Neurocsi Lett, 127:53-56, 1991.
  • GUZMAN-FLORES C, ALCARAZ M, FERNANDEZGUARDIOLA A: Rapid procedure to localize electrodes in experimental neurophysiology. Bol Est Med Biol (Mex), 16:29-31, 1958.
  • KUDO T, YAMAUCHI T: An ontogenic study of amygdala seizures induced by penicillin in rats. Exp Neurol, 102:254-260, 1988.
  • LA GRUTTA V, SABATINO M: Focal hippocampal epilepsy: Effect of caudate stimulation. Exp Neurol, 99:38-49, 1988.
  • LEHMENKÜHLER A, KERSTING U, NICHOLSON C: Diffusion of penicillin in agar and cerebral cortex of the rat. Brain Res, 444:181-183, 1988.
  • LOEB C, BO GP, SCOTTO A, BENASSI B, BESIO G, MINARDI P, FAVERIO A: GABA and phospholipids in penicillin-induced seizures. Exp Neurol, 90:278-280, 1985.
  • MAGOUN HW, RHINES R: An inhibitory mechanism in the bulbar reticular formation. J Neurophysiol, 9:165-171, 1946.
  • MARTINEZ A, FERNANDEZ-MAS R, FERNANDEZGUARDIOLA A: Efecto kindling producido por un foco epiléptico amigdalino inducido por penicilina, en preparaciones crónicas de gato. Estudio electroencefalográfico, polisomnográfico (registros de 24 horas) y de mapeo cerebral.Anales, Instituto Mexicano de Psiquiatría, 9:121- 128, 1994.
  • MARTINEZ-CERVANTES A, FERNANDEZ-MAS R, FERNANDEZ-GUARDIOLA A: Efecto de las microinyecciones repetidas de penicilina en el núcleo dorsal del rafe sobre la organización del sueño, durante registros de 23 horas, en el gato. Salud Mental (supl. 20):1:23-31, 1997.
  • MCDONALD AJ: Inmunohistochemical identification of gamma-aminobutyric acid-containig neurons in the rat basolateral amygdala. Neurosci Lett, 53:203-207, 1985.
  • MCLACHLAN RS, BIHARI F: Secondary generalization of seizures from a cortical penicillin focus following stimulation of the basan forebrain. Exp Neurol, 109:237-242, 1990.
  • NOEBELS JL, PEDLEY TA: Anatomic localization of topical applied [14C] penicillin during experimental focal epilepsy in cat neocortex. Brain Res, 125:293-303, 1977.
  • PINCE DA: Topical convulsant drugs and metabolic antagonists. En: Purpura DP, Penry JK, Tover D, Woodbury DM, Walter R (eds.). Experimental Models of Epilepsy. Raven Press, Nueva York, 1972.
  • SALGADO-BENITEZ A, BRIONES R, FERNANDEZGUARDIOLA A: Purkinje cell responses to a cerebral penicillin induced epileptogenic focus in the cat. Epilepsia, 23:597-606, 1982.
  • SCHNEIDERMAN JH, ARNOLD D, ADVANI A: Different changes in spontaneous field potentials oscillations precede epileptiform bursting in hippocampal slices perfused with penicillin or reduced magnesium. Brain Res, 553:275- 285, 1990.
  • SHIK ML, SEVERIN FV, ORLOVSKY GN: Control of walking and running by means of electrical stimulation of the mid-brain. Biophysics, 11:756-765, 1966.
  • SHOUSE MN: State disorder and state-dependent seizures in amygdala-kindled cats. Exp Neuol, 92:601-608,1986.
  • SINGH SI, MALHOTRA CL: Amino acid content of monkey brain. I. General pattern and quantitative value of glutamic acid/glutamine, gamma-aminobutyric acid and aspartic acid. J Neurochem, 9:37-42, 1962.
  • SNIDER RS, NIEMER WT: A Stereotaxic Atlas of the Cat Brain. University of Chicago Press, Chicago, 1961.
  • TANAKA A: Progressive changes of behavioral and electroencephalographic responses to daily amygdaloid stimulations in rabbit. Fukuoka Acta Med, 63:152-164,1972.
  • TESTA G, GLOOR P: Generalized penicillin epilepsy in the cat: effect of midbrain cooling. Electroenceph Clin Neurophysiol, 36:517-524, 1974.
  • URSIN R, STERMAN MB: A Manual for Standardized Scoring of Sleep and Waking Satates in the Adult Cat. University of California, Los Angeles, 1981.
  • WADA JA, SATO M: Generalized convulsive seizures induced by daily electrical stimulation of the amygdala in cats. Correlative electrographic and behavioral features.Neurology, 24:55-57, 1974.
  • WADA JA, MIZOGUCHI T, KOMAI S: Cortical motor activation in amygdaloid kindling: observations in non epileptic rhesus monkeys with anterior two-thirds callosal bisection. En: Wada JA (ed). Kindling 2. Raven Press,Nueva York, 1981.
  • WADA JA, MIZOGUCHI T: Limbic kindling in the forebrain bisected photosensitive baboon, papio papio. Epilepsia, 25:278-287, 1984.
  • WATSON K, LANTHORN TH: NMDA receptor antagonists attenuate a portion of the penicillin-induced epileptiform burst. Brain Res Bull, 24:765-768, 1990.
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