Revisión bibliográfica sobre el tratamiento hormonal con gonadotropina coriónica humana (hCG) y la hormona liberadora de hormona luteinizante (LHRH) en la Criptoquídea pediátrica

  1. María I. Plaza-Carmona 1
  2. Leticia Martínez-González 2
  3. Carmen Juan-García 1
  4. María Marcos-López 1
  1. 1 Hospital Universitario de León. León. España
  2. 2 Hospital Universitario Marqués de Valdecilla. Cantabria. España
Zeitschrift:
Nuberos científica

ISSN: 2173-822X

Datum der Publikation: 2019

Ausgabe: 3

Nummer: 28

Seiten: 38-43

Art: Artikel

DIALNET GOOGLE SCHOLAR lock_openOpen Access editor

Andere Publikationen in: Nuberos científica

Zusammenfassung

Introduction: Cryptorchidism means one or both testicles undescended, they are located anywhere between the abdominal cavity and the entrance of the scrotum. It is the one most prevalent congenital abnormality at birth, most of whom are premature male infants.Objective: This study has two aims. Firstly, to carry out a literature review about hormonal treatment of cryptorchidism with Human chorionic gonadotropin (hCG) and luteinizing hormone-realising hormone (LHRH). Secondly, to find out how to cope with the short- and long-term consequences of this treatment.Methods: A bibliography review related to subject was made from 01-01-2013 to 28-02-2017.Results: Most cases will go away on their own. Otherwise, if they do not, it is important to get treatment due to they may have long-term consequences for testicular function such as infertility or a higher chance of developing testicular cancer. Although there is a current trend towards the use of hormonal therapy in order to induce spontaneous testicular descent to the scrotum, the surgical therapy is the most common treatment.Conclusion: Hormonal therapy is not recommended for standard treatment due to its low use in routine clinical practice, as well as the different effects they cause. Longitudinal studies are needed to analyse its effects.

Bibliographische Referenzen

  • 1. Martínez-Mora J. Textbook intersexual states: disorders of sex differentiation. London; 1994. p. 26-38
  • 2. Happ J, Kollmann F, Krawehl C, Neubauer M, Beyer J. Intranasal GnRH therapy of maldescended testes. Horm Metab Res. 1975; 7(5):440-1.
  • 3. Loza-Cordero C, Mejía-Salas H. Caracterización clínico-epidemiológica de criptorquidia en pacientes internados del hospital del Niño Ovidio Aliaga Uría. Rev Med La Paz. 2017; 23(1):25-9.
  • 4. Blanco S, Gottlieb S, Grinspon R, Rey RA. Criptorquidia: desde la embriología al tratamiento. Rev Med Uis. 2015; 28(3):371-80
  • 5. Ortega-Páez E, Molina-Arias M. El uso previo de la ecografía retrasa injustifiadamente el tratamiento de la cirugía de la criptorquidia. Evid Pediatr. 2016: 12-8.
  • 6. Kaleva M, Toppari J. Cryptorchidism: an indicator of testicular dysgenesis? Cell Tissue Res. 2005; 322(1):167-72.
  • 7. Kolon T, Herndon C, Baker LA, Baskin L, Baxter C, Cheng E, et al. Evaluation and treatment of cryptorchidism: AUA guideline. J Urol. 2014; 192(2):337-45.
  • 8. Lechuga-Campoy JL, Lechuga-Sancho AM. Criptoquidia. Protoc diagn ter pediatr. 2011; 1:34-43.
  • 9. López-Cruz G, Pérez-Campos E, Hernández-Cruz P. Criptorquidia: Importancia del diagnóstico oportuno. Bol Clin Hosp Infant Edo Son. 2007; 27(1):32-7
  • 10. Menéndez R, Reveles M, Acosta E, Gómez C. Patología testicular benigna: hidrocele, criptorquidia y varicocele. Medicine-Programa de Formación Médica Continuada Acreditado. 2015; 11(83):4972-6.
  • 11. Álvarez-Muñoz V. Criptorquidia en el Principado de Asturias. Epidemiología y manejo diagnóstico y terapéutico. Oviedo: Universidad de Oviedo; 2016.
  • 12. Bu Q, Pan Z, Jiang S, Wang A, Cheng H. The effectiveness of hCG and LHRH in boys with cryptorchidism: a meta-analysis of randomized controlled trials. Horm Metab Res. 2016; 48(5):318-24.
  • 13. Penson D, Krishnaswami S, Jules A, McPheeters M. Effectiveness of hormonal and surgical therapies for cryptorchidism: a systematic review. Pediatrics. 2013; 131(6):1897-907.
  • 14. Cortes D, Holt R, de Knegt VE. Hormonal aspects of the pathogenesis and treatment of cryptorchidism. Eur J Pediatr Surg. 2016; 26(5):409-17
  • 15. Li T, Gao L, Chen P, Bu S, Cao D, Yang L, et al. A systematic review and meta-analysis of comparative studies assessing the efficacy of luteinizing hormone-releasing hormone therapy for children with cryptorchidism. Int Urol Nephrol. 2016; 48(5):635-44.
  • 16. Griffin D, Cambareri G, Kaplan G. Current Practice for Cryptorchidism: Survey of Pediatric Urologists. Urol Pract. 2017; 4(3):245-50.
  • 17. Cortes D, Thorup J, Visfeldt J. Hormonal treatment may harm the germ cells in 1 to 3-year-old boys with cryptorchidism. J Urol. 2000; 163(4):1290-2.
  • 18. Pyörälä S, Huttunen N, Uhari M. A review and meta-analysis of hormonal treatment of cryptorchidism. J Clin Endocrinol Metab. 1995; 80(9):2795-9.
  • 19. Tekgül S, Dogan HS, P. H. European Society for Paediatric Urology. Undescended testes.; Available from: http://uroweb.org/guideline/paediatric-urology/.
  • 20. Verkauskas G, Malcius D, Eidukaite A, Vilimas J, Dasevicius D, Bilius V, et al. Prospective study of histological and endocrine parameters of gonadal function in boys with cryptorchidism. J Pediatr Urol. 2016; 12(4): 238-e1.
  • 21. Feyles F, Peiretti V, Mussa A, Manenti M, Canavese F, Cortese M, et al. Improved sperm count and motility in young men surgically treated for cryptorchidism in the first year of life. Eur J Pediatr Surg. 2014; 24(5):376-80.
  • 22. Thorsson A, Christiansen P, Ritzén M. Effects of human chorionic gonadotropin on the normal testicular tissue of rats. Acta paediatr. 2007; 96(5):628-30.
  • 23. Zhao HT, He R, Sun J, Chen QM, Shi CR. Randomized controlled study of human chorionic gonadotrophin treatment for infantile cryptorchidism. Chin J Pediatr Surg. 2010; 31:797–9.
  • 24. Martin-Ritzén E, Bergh A, Bjerknes R, Christiansen P, Cortes D, Haugen SE, et al. Nordic consensus on treatment of undescended testes. Acta Paediatr. 2007; 96(5):638-43.
  • 25. Kolon TF, Herndon CDA, Bake rLA. American Urological Assocation. Evaluation and treatment of cryptorchidism: AUA guideline. J Urol. 2014; 192(2):337–45.
  • 26. Chua M, Mendoza J, Gaston M, Luna S, Morales M. Hormonal therapy using gonadotropin releasing hormone for improvement of fertility index among children with cryptorchidism: a meta-analysis and systematic review. J Pediatr Surg. 2014; 49(11):1659-67.
  • 27. Dunkel L, Taskinen S, Hovatta O, Tilly JL, Wikström S. Germ cell apoptosis after treatment of cryptorchidism with human chorionic gonadotropin is associated with impaired reproductive function in the adult. J Clin Invest. 1997; 100(9): 2341-6.
Fuente de los datos: Dialnet