COMPARISON OF METABOLIC PARAMETERS AND, PERIPHERAL AND CENTRAL OXYGENATION, BETWEEN HEALTHY AND TYPE 2 DIABETIC WOMEN.

Resumen

INTRODUCTION: Cardiorespiratory fitness (CRF) and fat oxidation (FO) are lower in sedentary women with diabetes compared to theirhealthy counterparts (1), however, the differences in other metabolic parameters, as resting FO, is unclear. A previous study suggests thatperipheral oxygenation may be impaired in the lower extremities in T2D (2), although, few studies have analysed the differences of peripheral and central between healthy women and women with T2D. The aim of this study was to analyse the differences of CRF, FO and peripheral and central oxygenation between healthy and women with T2D.METHODS: 17 women (33.8±14.9 years; 6 with T2D) were included in this study. Resting FO were registered through indirect calorimetry.Then, an incremental exercise protocol on a cycle ergometer with two phases was performed. The first phase aimed to determine maximalFO and consisted of 3-min steps of 15/30W (depending on the weight of the individual) maintaining a pedalling cadence of 60-80 rpm. Thisphase was stopped when RER≥1. The second phase to detect the VO2max. Near Infrared Spectroscopy (NIRS) at rest and during the incremental test was used. One NIRS sensor was placed on the non-dominant frontoparietal area for estimation of central oxygenation, whileanother sensor for estimation of peripheral oxygenation was placed on the vastus lateralis. Student t-test was applied to analyse the differences between groups.RESULTS: CRF was higher in healthy women compared to diabetics (p<0.001). Women with T2D showed higher resting FO than healthywomen (p=<0.002), however, these significant differences were not observed with maximal FO. Regarding resting peripheral oxygenation,there were significant differences between healthy and women with T2D, being higher in healthy individuals (P=0.002), however, womenwith T2D showed higher peripheral oxygenation at light, submaximal and maximal exercise intensity than healthy women (all p<0.005).There were no significant differences regarding central oxygenation.CONCLUSION: Women with T2D showed a higher FO at rest compared to healthy women. Moreover, women with T2D achieved higherperipheral oxygenation level during light, submaximal and maximal exercise intensity than healthy women, although, healthy womenshowed a higher peripheral oxygenation at rest. These findings suggest that women with T2D had higher peripheral oxygenation thanhealthy women during exercise.Grants: 1) PID2019-110063RA-I00. 2) PID2020-120034RA-I00. 3) LI19/21IN-CO09.References:1. Cancino Ramírez J, Soto Sánchez J, Zbinden Foncea H, et al. Cardiorespiratory fitness and fat oxidation during exercise as protectivefactors for insulin resistance in sedentary women with overweight or obesity. Nutr Hosp. 2018 Mar 1;35(2):312-317.2. Gildea, Norita, Joel Rocha, Adam McDermott, et al. 2019. “Influence of Type 2 Diabetes on Muscle Deoxygenation during Ramp Incremental Cycle Exercise.” Resp Phy and Neuro 269.