Citarabina liposomal para el tratamiento de la diseminación leptomeníngea en tumores del sistema nervioso central en niños y adolescentes
- Lucas Moreno
- Miguel Angel García Ariza
- Ofelia Cruz
- Carlota Calvo
- Jose Luis Fuster
- Jose Antonio Salinas
- Cristina Moscardo
- Raquel Portugal
- Jose Manuel Merino
- Luis Madero
ISSN: 1695-4033, 1696-4608
Ano de publicación: 2016
Volume: 85
Número: 5
Páxinas: 274-274
Tipo: Artigo
Outras publicacións en: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría ( AEP )
Resumo
Leptomeningeal dissemination in paediatric central nervous system (CNS) tumours is associated with a poor outcome, and new therapeutic strategies are desperately needed. One of the main difficulties in the treatment of CNS tumours is blood brain barrier penetration. Intrathecal therapy has shown to be effective in several paediatric tumours. The aim of this article is to review the data available on the use of liposomal cytarabine for paediatric patients with leptomeningeal dissemination of CNS tumours, including the pharmacology, administration route, safety and efficacy data.