Effects of physical exercise and diet on maximum fat oxidation capacity in Type 2 Diabetes Mellitus patients
- Manuel Costilla
- Rafa Baturone-Servan
- Carlos Morillas-Cantos
- Arturo Lamela Ortiz
- Juan Corral-Pérez
- Alberto Marín-Galindo
- Adrián Montes-de-Oca-García
- Jesús G. Ponce-González
Editorial: Instituto Politécnico de Setúbal – Escola Superior de Educação Centro de Investigação em Qualidade de Vida
ISBN: 978-989-35059-3-9
Ano de publicación: 2023
Páxinas: 87
Tipo: Achega congreso
Resumo
Maximum fat oxidation capacity (MFO) during exercise and its relative intensity respect of VO2max (FatMax) are markers of metabolic flexibility. An impaired metabolic flexibility is characteristic of metabolic diseases as Type 2 Diabetes Mellitus (T2DM). This study aims to determine the effects of exercise and diet on MFO and FatMax in T2DM patients. A randomized clinical trial was conducted on 99 T2DM patients with two types of physical exercise (moderate-intensity continuous training (MICT) or high-intensity interval training (HIIT)) isolated or combined with diet. A total of 6 groups were included: MICT, MICT+Diet, HIIT, HIIT+Diet, Inactive (Inac) or controls, and Inac+Diet. The supervised physical exercise sessions were conducted 3 times per week on cycloergometer. MICT consisted in 50 min at 10% over lactate threshold intensity, while HIIT consisted in 10 bouts of 1 min over 90% of peak power with 1 min of rest. Diet was balanced in macro and micronutrient with a caloric deficit of 350-500 kcal with personal interviews. MFO and FatMax were assessed by indirect calorimetry before and after the 12-week intervention with a gradual test with 15W increments every 3 minutes until RER achieved 1. A significant time x diet x traininginteraction was found for MFO (p=0.05). A main effect of time was found for FatMax (p=0.01). Bonferroni post-hoc comparisons showed a MFO augment only in MICT while FatMax improved in MICT and HIIT conditions (p<0.05). Neither diet condition nor controls showed statistically significant changes. Therefore, exercise can improve FatMax in T2DM patients independently of diet and modality of exercise. However, working at intensities near to MFO (~LT) improves this capacity but this not occurred with HIIT. Thus, HIIT and MICT can improve metabolic flexibility in T2DM patient but only MICT improves MFO during exercise.