Importancia de las aplicaciones clínicas de la Proteómica

Abstract

The practical usefulness of the results of Proteomics in relation to health is very important. The discovery of protein markers of diseases such as cardiovascular, neurological, oncologic, metabolic, among others, has an immediate clinical application in the diagnosis, monitoring and treatment of these diseases. The Human Proteome Organization (HUPO, www.hupo.org) was established in 2001 to promote greater awareness of the importance of proteomics and opportunities in the diagnosis, prognosis and treatment of diseases. It has subsequently formed several groups: HPPP (Human Plasma Proteome Project), HLPP (Human Liver Proteome Project), PSI (Proteome Standards Initiative), HBPP (Human Brain Proteome Project) and MRPP (Mouse and Rat Proteome Project). One of the main goals of proteomics is the identification of markers of disease. One approach has been to compare the expression of proteins in normal and diseased tissues to identify proteins that are expressed abnormally and may represent new markers. Another strategy is the analysis of proteins in segregated cell lines and primary cultures and finally, obtaining serum protein profiles. Proteomic studies are gaining a higher profile in recent years, mainly in its application to human pathology. To this end a large number of studies are being conducted in human plasma, tissues and various body fluids